Devil May Cry 2 begins with Lucia and Dante separately entering a museum where an important item called the Medaglia is stored. After defeating a group of demons in the museum, Lucia invites Dante to follow her to the Dumary Island, where he is introduced to Matier, her mother. Matier explains that she once fought alongside Dante's father, Sparda, to defend the island against demons. She asks Dante to help fight Arius, an international businessman who is using demonic power in an effort to conquer the world. Dante flips a coin in answer, and decides to help when the coin lands on heads. After Dante leaves, Matier and Lucia discuss the Arcana, the items required for Arius to raise the demon Argosax.
Lucia eventually confronts Arius, who reveals that she was his creation. When she moves to strike him, he uses his magic to blast her away. Shortly afterward, Dante meets up with Lucia, who gives him the last of the Arcana before leaving. Dante then encounters Matier and tries to pass the Arcana to her. Matier, in turn, asks Dante to take the Arcana to save Lucia, who has gone to fight Arius again. Dante flips the coin again to decide if he will help; it lands on heads, and he departs to aid Lucia. Meanwhile, Lucia enters the Uroboros tower and attacks Arius, who captures her. Dante arrives and trades the Arcana for Lucia, then attacks Arius. To escape, Arius forces Dante to decide between saving Lucia or killing him
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